Sulfur Amino Acid Status Controls Selenium Methylation in Pseudomonas tolaasii: Identification of a Novel Metabolite from Promiscuous Enzyme Reactions
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منابع مشابه
Identification and synthesis of a novel selenium-sulfur amino acid found in selenized yeast: Rapid indirect detection NMR methods for characterizing low-level organoselenium compounds in complex matrices.
After proteolytic digestion, aqueous extraction, and derivatization with diethyl pyrocarbonate or ethyl chloroformate, HPLC-inductively coupled plasma (ICP)-MS, GC-atomic emission detection (AED), and GC-MS analysis of high-selenium yeast stored at room temperature for more than 10 years showed selenomethionine as the major Se product along with substantial amounts of selenomethionine selenoxid...
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The iron-sulfur protein putidaredoxin from Pseudomonas putida contains 106 amino acids arranged in a single peptide chain. The complete amino acid sequence has been determined. The molecular weight including 2 atoms each of iron and sulfur is 11,594. The molecule contains 6 cysteine residues. It is suggested that positions 39, 45, 48, and 85 (or 86) may be chelated to the iron in the iron sulfi...
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Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metabolite as a sulfur-linked dimer was proposed on the basis of spectral and chemi...
متن کاملA branch point of Streptomyces sulfur amino acid metabolism 1 controls the production of albomycin
7 a Department of Biological Sciences, Ohio University, Athens, OH 45701, USA 8 b Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, 9 Lexington, KY 40536, USA 10 c Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin 11 University, Tianjin 300072, P.R. China 12 13 *Address Correspondence to Shawn Chen, [email protected] 1...
متن کاملA Branch Point of Streptomyces Sulfur Amino Acid Metabolism Controls the Production of Albomycin.
Albomycin (ABM), also known as grisein, is a sulfur-containing metabolite produced by Streptomyces griseus ATCC 700974. Genes predicted to be involved in the biosynthesis of ABM and ABM-like molecules are found in the genomes of other actinomycetes. ABM has potent antibacterial activity, and as a result, many attempts have been made to develop ABM into a drug since the last century. Although th...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 2021
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.00104-21